Optimization of plasma amplifiers

Plasma amplifiers offer a route to side-step limitations on chirped pulse amplification and generate laser pulses at the power frontier. They compress long pulses by transferring energy to a shorter pulse via the Raman or Brillouin instabilities. We present an extensive kinetic numerical study of the three-dimensional parameter space for the Raman case. Further particle-in-cell simulations find the optimal seed pulse parameters for experimentally relevant constraints. The high-efficiency self-similar behavior is observed only for seeds shorter than the linear Raman growth time. A test case similar to an upcoming experiment at the Laboratory for Laser Energetics is found to maintain good transverse coherence and high-energy efficiency. Effective compression of a 10 kJ , nanosecond-long driver pulse is also demonstrated in a 15-cm-long amplifier

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis ( RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory arthritis of duration 3 months or less, whose outcomes were subsequently determined by follow up. For comparison, synovial fluid was aspirated from patients with acute crystal arthritis, established RA and osteoarthritis. Rheumatoid factor activity was blocked in the synovial fluid samples, and a panel of 23 cytokines and chemokines measured using a multiplex based system. Patients with early inflammatory arthritis who subsequently developed RA had a distinct but transient synovial fluid cytokine profile. The levels of a range of T cell, macrophage and stromal cell related cytokines ( e. g. IL-2, IL-4, IL-13, IL-17, IL-15, basic fibroblast growth factor and epidermal growth factor) were significantly elevated in these patients within 3 months after symptom onset, as compared with early arthritis patients who did not develop RA. In addition, this profile was no longer present in established RA. In contrast, patients with non-rheumatoid persistent synovitis exhibited elevated levels of interferon-gamma at initiation. Early synovitis destined to develop into RA is thus characterized by a distinct and transient synovial fluid cytokine profile. The cytokines present in the early rheumatoid lesion suggest that this response is likely to influence the microenvironment required for persistent RA

Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat

Nanomaterial of titanium dioxide (TiO2) is manufactured in large-scale production plants, resulting in risks for accidental high exposures of humans. Inhalation of metal oxide nanoparticles in high doses may lead to both acute and long-standing adverse effects. By using the Dark Agouti (DA) rat, a strain disposed to develop chronic inflammation following exposure to immunoactivating adjuvants, we investigated local and systemic inflammatory responses after lung exposure of nanosized TiO2 particles up to 90 days after intratracheal instillation. TiO2 induced a transient response of proinflammatory and T-cell-activating cytokines (interleukin [IL]-1α, IL-1β, IL-6, cytokine-induced neutrophil chemoattractant [CINC]-1, granulocyte-macrophage colony-stimulating factor [GM-CSF], and IL-2) in airways 1-2 days after exposure, accompanied byaninfluxofeosinophilsand neutrophils. Neutrophil numbers remained elevated for 30 days, whereas the eosinophils declined to baseline levels at Day 8, simultaneously with an increase of dendritic cells and natural killer (NK) cells. The innate immune activation was followed by a lymphocyte expansion that persisted throughout the 90-day study. Lymphocytes recruited to the lungs were predominantly CD4+ helper T-cells, but we also demonstrated presence of CD8+T-cells, B-cells, and CD25+T-cells. In serum, we detected both an early cytokine expression at Days 1-2 (IL-2, IL-4, IL-6, CINC-1, IL-10, and interferon-gamma [IFN-γ] and a second response at Day 16 of tumor necrosis factor-alpha (TNF-α), indicating systemic late-phase effects in addition to the local response in airways. In summary, these data demonstrate a dynamic response to TiO2 nanoparticles in the lungs of DA rats, beginning with an innate immune activation of eosinophils, neutrophils, dendritic cells, and NK cells, followed by a long-lasting activation of lymphocytes involved in adaptive immunity. The results have implications for the assessment of risks for adverse and persistent immune stimulation following nanoparticle exposures in sensitive populations

Anteckningar i räknemetodik för småskolan och folkskolan

1:a upplaga

Design and modeling of a self-sufficient shape-memory-actuator

In machine tools several time and position varying heat sources causes complex temperature distributions. The resulting problems are varying thermal deformations which cause a loss of accuracy as well as non optimal drive conditions. An option to deal with that issue is to use structure integrated SM-actuators which use the thermal energy accumulated by machining processes to yield an actuator displacement. That creates a structure inherent control loop. There the shape-memory-elements work as sensing element as well as actuation element. The plant is defined by the thermal and mechanical behaviour of the surrounding structure. Because of the closed loop operation mode, the mechanical design has to deal with questions of stability and parameter adjustment in a control sense. In contrast to common control arrangements this issues can only be influenced by designing the actuator and the structure. To investigate this approach a test bench has been designed. The heat is yielded by a clutch and directed through the structure to the shape memory element. The force and displacement of the actuator are therefore driven directly by process heat. This paper presents a broad mechanical design approach of the test bench as well as the design of the SMactuator. To investigate the thermo-mechanical behaviour of the structure-integrated actuator, a model of the test bench has been developed. The model covers the thermal behaviour of the test bench as well as the thermo-mechanical couplings of the shape memory actuator. The model has been validated by comprehensive measurements

Dreidimensionaler Textilstrukturmaterialkörper und Verfahren zur Herstellung desselben

The body has a pile yarn (3) and a helical spring element co-determining a three dimensional structure and made of shape-memory material e.g. thermal shape-memory alloy, shape-memory polymer and magnetic shape-memory alloy. Another pile yarn (4) i.e. monofilament, is provided adjacent to the former pile yarn. Two textile cover layers (1, 2) are connected with each other and are provided at a distance from each other by the pile yarns. A sensor e.g. pressure- and/or temperature sensor, detects a loading condition and/or rigidity of zones of the body. An independent claim is also included for a method for manufacturing a three dimensional textile structure material body